Double salts of gold hydrocyanic acids and process of making same.



. without EIMTED ETATES PATENT OFFICE.

GUSTAV SPIESS AN D ADOLF FELDT, 0F FRANKFORT-ON-THE-MAIN, GERMANY, ASSIGN- 0136 TO FARBWERKE VCR/M. MEISTER LUGIUS &

BBU'NING; OF HGCHST-QN-THE- MAIN, GERMANYQA CORPORATION OF GERJHANY.

DOUBLE SALTS 0F GGLD HYDROCYANIC ACIDS AND PROCESS OF MAKING SAME.

1,115,668. No Drawing.

'Ph. D, doctor of medicine, citizens of the and Russia, respec- Empires of Germany tively, residing at F rankfort-on-the-Main, Germany, have invented certain new and useful Improvements in Double Salts of Gold Hydrocyanic Acids and Processes of Making Same, of which the following is a specification.

It is'known that the complex gold-hydrocyanic acids and their salts possess a strong destructive action uponmicroorganisms and consequently, when introduced into the animal body, they have a great curative efl'ect. Now We have found that the disinfecting power of said acids in the animal organism protecting the said complex gold-hydrocyanic acids immediate reduction, Which prounstable from an tection can be effected by forming doublesalts with organic nitrogenous bases, which salts are obtained by treating the bases or their salts with a'gold-hydrocyanic acld or its salt, The products thus obtained most probably correspond to the general formula:

BN HCNAuC/N an organic nitrogevvherein EN stands for nous base, and HCN.AuCN for a complex gold-hydrocyanic acid. They are colorless to yellow crystals, Which dissolve in Water decomposition and Which are soluble in ether and benzine and,

scarcely I decompose, leaving metallic on heating, gold. M

The following examples illustrate our invcntion:

Example I: 4.5 grams of the hydrocholrid of 1-phenyl-2.3 dirnethyl--aminofi-pyrazolone, dissolved in 2-5 cc. of ivater, are added to a solution of 7 grams of potassium auricyanid which are also dissolved in cc. of Water. After a short time, the double-salt separates as crystals forming faint yellovvish-hroivn laminae, melting at 196-l98 C. They dissolve in Water in the proportion of 1 :120. They contain 39.19 per cent. of gold (theoIieL QaJLy calculated 39:01 per centj.

Specification of Letters Patent. Application filed January 16,- 1914. Serial No. 812,575.

Example II: 5 grams of the hydrochlorid of 1-phenyl2.3-dimethyl-4-dimethylamino- 5-pyrazolone are dissolved in 25 cc. of Water and there is added a solution of 7 grams of potassium auricyanid dissolved in 25 cc. of Water. The double-salt separates at once as crystals forming small colorless laminae, melting at l83l85 C. In cold Water the salt is scarcely soluble and it contains a percenltage of gold corresponding to the formu a:

Example III: 5 grams of potassium auro- -cyanid are Well stirred With 10 cc. of Water and 3 grams of cholin-hydrochlorid are added, whereupon complete solution-occurs. After having allowed this solution to stand for 24 hours,'the resulting potassium chlorid is precipitated With absolute alcohol and the alcoholic filtrate is evaporated in cacao. The remaining crystalline mass is pressed out upon a clay-plate and dried over concentrated sulfuric acid. The cholin-aurncyanid melts at 80-83 C. it is very readily soluble in Water. The percentage of gold conltained therein corresponds to, the formu a:

Example IV: 4 grams of piperazin hydrochlorid are-dissolved in cc. of Water and there is added a solution of 9 grams of potassium aurocyanid in 100 cc. of Water. The auric double-salt separates at once in the form of long needles of a faint pink color. These needles are filtered off and Washed with cold Water. The piperazin aurocyanid n n enonauon begins to sinter at about 240 C. and melts at 252255 C. It is rather difiicultlysoluble in Water. The percentage of gold found to be contained therein is 67.29 (theoretically calculated 67.24:).

aving now described our invention, What we claim is:

1. The process of preparing double-salts of gold-hydrocyanic acids with organic nitibgenous bases, which co sists in treating Patented Nov. 3,1914. 7

the respective organic bases with euro-hydrocyanic acid. f

' 2. As new products, gold hydrocyanids of organic-nitrogenous bases' which correspond to the forrnulaz' wherein BN stands for an or anic nitrogenous base, and HCN.AuCl\ for a compleX gold-hydrocyanic acid, being colorless to yellow crystals, which dissolve in Water Wlt-llOllt decomposition, and which are scarcely soluble in ether and benzene and,

when heated, gold. A

3. As a new product, the aurihydrocyanid decompose, leaving metallic of l-Phenyl-Q.3-dimethyl-4dimethylemino 5-pyrazolone of the constitution:

being colorless lamina, melting at 183- 185 C., slightly soluble in cold water.

scarcely soluble in ether and benzene and 

